Huntington’s disease

Findings show high-dose thiamine and biotin treatments can restore normal processes

Results reveal possible new therapeutic targets for mental and neurological disorders

UCI has launched a Center for Neurotherapeutics to facilitate drug discovery for neurological diseases. It’s led by Dr. Albert LaSpada, Distinguished Professor of pathology, neurology and biological chemistry, as well as associate dean for research development at the UCI School of Medicine; and Robert Spitale, professor and associate dean of research at the UCI School […]

Renewal recognizes UCI’s dedication to patient care and active engagement in research to develop new therapeutic approaches

Sue & Bill Gross Stem Cell Research Center celebrates 10 years of innovation

Leslie Thompson of the Sue & Bill Gross Stem Cell Research Center and UCI MIND has been awarded $6 million by the California Institute for Regenerative Medicine to continue her CIRM-supported efforts to create stem cell treatments for Huntington’s disease. The funding will allow the Thompson lab to conduct the late-stage testing needed to apply […]

UCI-led stem cell study points to new treatments for this fatal disorder

A study appearing April 14 in the journal Neuron suggests there may be a new way to change the damaging course of Huntington disease. University of California, Irvine neurobiologists Leslie Thompson and Joseph Ochaba and their colleagues from UCI and from Children’s Hospital of Philadelphia have shown that reducing the aberrant accumulation of a particular form of the […]

By identifying in spinal fluid how the characteristic mutant proteins of Huntington’s disease spread from cell to cell, UC Irvine scientists and colleagues have created a new method to quickly and accurately track the presence and proliferation of these neuron-damaging compounds – a discovery that may accelerate the development of new drugs to treat this incurable disease.

UCI staffer co-founds support group for Huntington’s disease research, care on campus