COVID-19 antibodies appear to wane rapidly, so prepare for booster shots, study suggests

A large-scale study by UC Irvine researchers in the spring found that mRNA vaccines like Pfizer and Moderna provided much greater protection against COVID-19 than did natural infection alone. “We agree that many people who had a prior natural SARS-CoV-2 asymptomatic exposure or a PCR confirmed infection respond with a higher (antibody) response than people who are completely naïve,” said Dr. Philip Felgner, the lead researcher at UCI [and director of UC Irvine’s Vaccine Research and Development Center and Protein Microarray Laboratory and Training Facility]. “But since natural exposure indices a wide range of serological response, I would stop short of recommending that everyone who had a prior exposure should only get one shot.”