How can it be safe to open up when you’re still asking residents to batten down? “If we could learn from these things and practice moderation — not go straight from ‘no’ to ‘yes’ on all fronts, then maybe we can mitigate transmission,” said Dr. Shruti Gohil, associate medical director of epidemiology and infection prevention at UC Irvine. “But it’s hard. How do we message that nuance?” When it comes to COVID-19, it’s not always a matter of “you open, you don’t open. Maybe you open with restrictions,” she said Tuesday.