Philip L. Felgner and his colleagues at UCI’s Vaccine Research and Development Center are studying the strength of immunity over time in vaccinated health care workers at the UCI Medical Center. After six months, they’ve found that the immune response appears durable, declining by only about 10% from the peak. “Based on our data, it looks like an annual boost — similar to what we expect to get for the flu vaccine — may be recommended,” said Felgner, [professor of public health and] director of the center. … “COVID has capacity to surprise us. I know for sure we’ll have at least one other wave before this is all over,” [said Andrew Noymer, a UCI associate professor of public health].