Steve Zylius / University Communications “Memory is important to understand because it’s our most precious ability,” says UCI neurobiologist James McGaugh, senior author of a new paper on highly superior autobiographical memory. “Our memories are what define us as individuals.”

Making memories

UC Irvine scientists have discovered intriguing variations in the brains of people who can effortlessly recall every moment of their lives since about age 10.

Memory Lane is way more crowded for some people, and UC Irvine scientists are beginning to understand why. They’ve discovered intriguing variations in the brains of an extraordinary group who can effortlessly recall most moments of their lives since about age 10 – among them film and TV star Marilu Henner.

The phenomenon of highly superior autobiographical memory – first documented in 2006 by UCI neurobiologist James McGaugh and colleagues in a woman identified as “AJ” – has been profiled on CBS’s “60 Minutes” and in hundreds of other media outlets. But a new paper in the July issue of Neurobiology of Learning & Memory offers scientific insights about nearly a dozen individuals with this uncanny ability.

All were found to have variations in nine structures of their brains compared to those of control subjects, including more robust white matter linking the middle and front parts. Most of the differences are in areas known to be linked to autobiographical memory, “so we’re getting a descriptive, coherent story of what’s going on,” says lead author Aurora LePort, a doctoral candidate at UCI’s Center for the Neurobiology of Learning & Memory.

Surprisingly, the people with stellar autobiographical memory did not score higher on routine laboratory memory tests or when asked to use rote memory aids. Yet when it came to public or private events that occurred after age 10½, “they were remarkably better at recalling the details of their lives,” says McGaugh, senior author on the new work.

“These are not memory experts across the board. They’re 180 degrees different from the usual memory champions who can recite pi to a large degree or other long strings of numbers,” LePort notes. “It makes the project that much more interesting; it really shows we’re homing in on a specific form of memory.”

She says interviewing the subjects is “baffling. You give them a date, and their response is immediate. The day of the week just comes out of their minds; they don’t even think about it. They can do this for so many dates, and they’re 99 percent accurate. It never gets old.”

The study also found statistically significant evidence of obsessive-compulsive tendencies among the group, but the authors do not yet know if or how this aids recollection. Many of the individuals have large, minutely cataloged collections of some sort, such as magazines, videos, shoes, stamps or postcards.

UCI researchers and staff have assessed more than 500 people who thought they might possess highly superior autobiographical memory and have confirmed 33 to date, including the 11 in the paper. Another 37 are strong candidates who will be further tested.

“The next step is that we want to understand the mechanisms behind the memory,” LePort says. “Is it just the brain and the way its different structures are communicating? Maybe it’s genetic; maybe it’s molecular.”

McGaugh adds: “We’re Sherlock Holmeses here. We’re searching for clues in a very new area of research.”

Fellow authors are Aaron Mattfeld, Heather Dickinson-Anson, James Fallon, Craig Stark, Frithjof Kruggel and Larry Cahill. Funding was provided by the National Institutes of Health, the Gerard Family Trust and Unither Neurosciences Inc.

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